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dc.contributor.authorKafeero, Hussein Mukasa
dc.contributor.authorKawooya, Abubaker
dc.contributor.authorNamusoke, Mariam
dc.contributor.authorAtiku, Saad
dc.contributor.authorMugambwa, Joseph
dc.date.accessioned2018-02-16T08:53:24Z
dc.date.available2018-02-16T08:53:24Z
dc.date.issued2016
dc.identifier.citationKafeero, H.M ... et al (2016) The S-Gene Mutations in the Circulating HBV Genotypes/Sub-Genotypes Associated with Hepatitis B Infection in Uganda and their Effects on Cytokines Expression in Liver Disease Progression. Global Journal of Medical Research. Vol.16(2)en_US
dc.identifier.issn0975-5888
dc.identifier.urihttp://hdl.handle.net/20.500.12309/492
dc.description.abstractThe causal agent for hepatitis B is called hepatitis B virus (HBV). It is a partially double stranded circular DNA virus of the family Hepadnaviridae. It has been implicated as the leading cause of hepatocellular carcinoma and only second to tobacco among the global human carcinogens. Liver damage as a result of HBV infection is due to host immune response and is modulate by cytokines. The HBV is classified into 10 genotype denoted as A, B, C, D, E, F, G, H, I and J together with several sub-genotypes which have diverse geographical distribution. These genotypes influence liver disease progression and severity as well as response to antiviral therapies. Mutations in the S-gene have been implicated in the paradoxical coexistence of HBsAg and the anti-HBs antibodies which is associated with advanced liver diseases including hepatocellular carcinoma and liver cirrhosis.en_US
dc.language.isoenen_US
dc.publisherGlobal Journal of Medical Researchen_US
dc.subjecthepatitis B virusen_US
dc.subjectenotypesen_US
dc.subjectcytokinesen_US
dc.subjectmutationsen_US
dc.titleThe S-Gene Mutations in the Circulating HBV Genotypes/Sub-Genotypes Associated with Hepatitis B Infection in Uganda and their Effects on Cytokines Expression in Liver Disease Progressionen_US
dc.typeArticleen_US


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