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Development of Plasmodium falciparum specific naïve, atypical, memory and plasma B cells during infancy and in adults in an endemic area

Lugaajju, A; Reddy, S. B.; Wahlgren, M; Kironde, Fred; Persson, K. E. M. (Bio Med Central, 2017)

Background: B-cells are essential in immunity against malaria, but which sub-sets of B-cells specifically recognize Plasmodium falciparum and when they appear is still largely unknown. Results: Using the flow cytometry ...

Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens

Reddy, S. B.; Anders, R. F.; Cross, N; Mueller, I; Senn, N; Stanisic, D. I.; Siba, P. M.; Wahlgren, M; Kironde, Fred; Beeson, J. G.; Persson, K. E. M (2015)

Background: Malaria is a major global cause of deaths and a vaccine is urgently needed. Results: We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled them in ...