|Abstract:Introduction: COVID-19 is one of the huge health burdens on the earth in the recent times. Massive campaigns on the adherence to standard operation procedures (SOPs) have been emphasized by the Government of Uganda and even the county has been put in two lockdowns to curtail the spread of this disease. Despite all these efforts, market vendors in Sironko district have seemingly not complied with these SOPs and this makes them potential hotspot for disease transmission, but no qualitative study has so far been documented. Therefore, the current study investigated the adherence of SOPs for COVID-19 amongst market vendors in this area. Methodology: A qualitative survey research design was adopted and a total of 53 participants, selected by both purposeful and simple random were involved. Interview, focus group discussion and observations techniques were used in data collection. The date was analyzed by the statistical software called MedCalc, version 20.0008 Results: The result showed that 65 % were females, most were aged between 29 females aged between 31-40 year took part in the study contributing 55% to the total subjects and married and of which 37 (70 %) were married. The market experienced challenges of inadequate & inappropriate facilities for SOPs but water was abundant (45, 85 %). All the SOPs for COVID-19 were flouted in these markets. Conclusions: Market vendor rarely adhered to SOPs for COVID-19 and this makes them a potential source for transmission of COVID-19 to the local communities in the entire sub-regions. Therefore, there is need for department of production in Sironko district to re-enforce observance to SOPs guidelines for COVID-19 in this area.